Schizophrenia Gene Mutation Found; Target for New Drugs

In a major advance for schizophrenia research, an international team of  scientists, led by Jonathan Sebat, PhD, assistant professor of psychiatry and cellular and molecular medicine at the University of California, San Diego School of Medicine, has identified a gene mutation strongly linked to the brain disorder – and a signaling pathway that may be treatable with existing compounds.

The work poses significant and immediate implications for neurobiology and the treatment of schizophrenia because the gene identified by the researchers is an especially attractive target for drug development.

''In some ways, this is the kind of gene that the pharmaceutical industry has been waiting for,'' said Sebat, who is also chief of the Beyster Center for Molecular Genomics of Neuropsychiatric Diseases and a member of the Institute for Genomic Medicine, both at UC San Diego. ''Its activity can be modulated by synthetic peptides; and some have already been created.''

The findings are published in the 3 February 2011 online issue of the journal Nature.

Schizophrenia is a chronic, severe and disabling brain disorder, with symptoms that include hallucinations, delusions and thought disorders. It is believed to be caused by environmental and genetic factors, most notably the latter: the illness occurs in 1 per cent of the general population, or 10 per cent of people who have a first-degree relative with the disorder, such as a parent or sibling.

In previous work, Sebat and collaborator Mary-Claire King, a professor of medical genetics at the University of Washington, discovered that rare mutations at many locations in the human genome resulted in significantly higher risk of schizophrenia.